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Updated: Jul 6, 2026

Murine Fetal Echocardiography
Published on: February 15, 2013
The development of the fetal thymus: an in utero sonographic evaluation
Yaron Zalel1, Ronni Gamzu, Shlomo Mashiach
1Department of Obstetrics and Gynecology, The Chaim Sheba Medical Center, Tel-Hashomer, Ramat Gan, Israel. zalel_y@netvision.net.il
Objectives:
To establish a nomogram for fetal thymus size during gestation.
Methods:
The study is a prospective, cross sectional evaluation of 403 male and female fetuses between 14 and 38 weeks of normal singleton pregnancies. Measurements of fetal thymus size were performed by high resolution transvaginal ultrasonography between 14 and 17 weeks' gestation, and by transabdominal ultrasonography after 18 weeks' gestation.
Results:
Adequate thymus size measurements were obtained in all 403 fetuses. Thymus size as a function of gestational age was expressed by the regression equation: (square root) thymus size (mm)= -39.39+4.41 x gestational age (weeks). The correlation coefficient, r=0.965, was found to be highly statistically significant (p<0.0001). The normal mean and the 90% prediction limits were defined.
Conclusion:
The present data offer the normal range of fetal thymus size from early stages of gestation that may allow intrauterine assessment of its development. It may be helpful in the prenatal diagnosis of thymic pathologies.
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