[Characteristics of arrhythmia and late ventricular potentials in patients with cardiological syndrome X]

Area of Science:

• Cardiology
• Electrophysiology
• Pathophysiology

Context:

• Cardiological syndrome X (SX) and atherosclerotic coronary artery disease (ACA) share similarities in clinical presentation and risk factors.
• Late ventricular potentials (LVP) are a marker of arrhythmogenic substrate, but their significance in SX versus ACA is not fully understood.
• Understanding LVP in these conditions is crucial for risk stratification and management of ventricular arrhythmias.

Purpose:

• To comparatively analyze late ventricular potentials (LVP) in patients with cardiological syndrome X (SX) and atherosclerotic coronary artery disease (ACA).
• To investigate the relationship between LVP and arrhythmia, cardiac contractility, lipid metabolism, and myocardial morphology in both patient groups.
• To determine the predictive value of LVP for severe ventricular arrhythmias in SX and ACA.

Summary:

• No significant differences were found in the frequency and severity of arrhythmias or LVP detection between SX and ACA patients.
• Patients with LVP in both groups exhibited a higher frequency of high-grade ventricular arrhythmias compared to those without LVP.
• Diffuse cardiosclerosis foci are identified as the likely anatomical substrate for LVP, with correlations observed between SAHR ECG parameters, contractility, and lipid metabolism in SX patients.

Impact:

• The risk of severe ventricular arrhythmias is comparable between SX and ACA patients.
• LVP serves as a valuable predictor of severe ventricular arrhythmias in both SX and ACA.
• This study aids in risk stratification and informs therapeutic strategies for patients with these cardiac conditions.