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Updated: Sep 8, 2026
A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
Published on: June 9, 2014
Association of calcitonin receptor gene polymorphism with early marginal bone loss around endosseous implants
Yasuhiro Nosaka1, Yoichi Tachi, Hitomi Shimpuku
1Department of Dentistry and Oral-Maxillofacial Surgery, Kobe Nishi City Hospital, Kobe, Japan. nosasen@aol.com
Purpose:
This study investigated the relationship between calcitonin receptor (CTR) genotype and buccal marginal bone loss observed at stage II surgery for endosseous implants.
Materials And Methods:
A total of 237 implants were placed in 35 patients; 89 implants were placed in maxillae and 148 implants in mandibles. The CTR genetic polymorphism was examined by the polymerase chain reaction restriction fragment length polymorphism method.
Results:
Patients with the TC genotype were 20 times more likely to suffer buccal marginal bone loss in the mandible than patients with the CC genotype. Furthermore, there were no significant differences in the distribution of age, smoking status, postmenopausal women, and bone quality between patients with and without bone loss in either jaw.
Discussion:
These results suggest that the known risk factor for bone loss cannot explain the early marginal bone loss around the implants.
Conclusion:
Although further genetic research should be conducted, it is suggested that the CTR genetic test could become a useful tool in the planning of treatment before implant surgery and lead to more predictable implant treatment.
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