Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Familial Hypercholesterolemia.

Paul N. Hopkins1

  • 1Cardiovascular Genetics Research, University of Utah School of Medicine, 410 Chipeta Way, Room 167, Salt Lake City, UT 84108, USA. paul@ucvg.med.utah.edu

Current Treatment Options in Cardiovascular Medicine
|February 23, 2002
PubMed
Summary

Familial hypercholesterolemia (FH) is a common genetic condition causing high LDL cholesterol. Early diagnosis and aggressive combination drug therapy, including statins, can help manage FH and regress coronary lesions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same journal

An Update on the Role of Renal Artery Denervation in the Treatment of Hypertension.

Current treatment options in cardiovascular medicine·2026
Same journal

Advancements and Challenges in Contemporizing Care for Adult Patients with Congenital Heart Disease and Advanced Heart Failure: An Update on Application of Modern Heart Failure Technologies.

Current treatment options in cardiovascular medicine·2026
Same journal

Evolving Decongestion Strategies in the Management of Acute Heart Failure.

Current treatment options in cardiovascular medicine·2025
Same journal

Advanced Electroanatomic Mapping: Current and Emerging Approaches.

Current treatment options in cardiovascular medicine·2025
Same journal

Metabolic Reprogramming in Heart Failure: From Energy Starvation to Therapeutic Targets.

Current treatment options in cardiovascular medicine·2025
Same journal

Drug-Coated Balloons for Coronary Artery Disease: From Theory to Practice.

Current treatment options in cardiovascular medicine·2025

Area of Science:

  • Cardiology
  • Genetics
  • Metabolic Disorders

Background:

  • Familial hypercholesterolemia (FH) is a prevalent, severe genetic disorder characterized by elevated plasma low-density lipoprotein (LDL) cholesterol.
  • FH remains under-recognized and under-treated, despite the availability of effective lipid-lowering therapies.
  • The MEDPED (Make Early Diagnoses, Prevent Early Deaths) organization was established globally to identify and support individuals with FH.

Purpose of the Study:

  • To highlight the challenges in diagnosing and treating FH.
  • To emphasize the need for aggressive therapeutic strategies in FH management.
  • To present evidence for the efficacy of combination therapy in FH patients.

Main Methods:

  • Review of existing literature on FH diagnosis and treatment.
  • Description of the MEDPED initiative for global FH identification.
  • Analysis of treatment outcomes in FH patients receiving various lipid-lowering medications.

Main Results:

  • Some FH patients achieve LDL goals with statin monotherapy.
  • Many FH patients require combination therapy (statin, bile acid sequestrant, niacin) to reach LDL targets.
  • Aggressive treatment led to regression of coronary lesions in FH patients.

Conclusions:

  • FH is a significant public health issue requiring improved detection and management.
  • Combination drug therapy is often necessary for effective LDL cholesterol reduction in FH.
  • Intensive lipid-lowering treatment can improve cardiovascular outcomes in FH by regressing coronary artery disease.

Related Experiment Videos