Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Evidence based vaccinology.

David R Nalin¹

¹Merck Vaccine Division, Merck and Company, P.O. Box 4, WP97A-343, West Point, PA 19486-0004, USA. david_nalin@merck.com

|February 23, 2002

Summary

This summary is machine-generated.

Evidence-based vaccinology (EBV) uses the best scientific evidence for vaccine development, manufacturing, and use. This approach ensures vaccine safety, effectiveness, and public confidence through rigorous data-driven decisions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The History of Intravenous and Oral Rehydration and Maintenance Therapy of Cholera and Non-Cholera Dehydrating Diarrheas: A Deconstruction of Translational Medicine: From Bench to Bedside?

Tropical medicine and infectious disease·2022

Same author

Effectiveness of hepatitis A vaccine in a former frequently affected community: 9 years' followup after the Monroe field trial of VAQTA.

Vaccine·2002

Same journal

V-safe: Summary of findings reported after COVID-19 vaccination to a US CDC active safety surveillance system through June 2023.

Vaccine·2026

Same journal

In silico selection and in vivo evaluation of scoloptoxin SSD14, Rm-inositol monophosphatase, and Rm-neprilysin as potential anti-tick vaccines.

Vaccine·2026

Same journal

Phase 1 trial of intranasal NDV-HXP-S in previously vaccinated adults.

Vaccine·2026

Same journal

Effect of malaria parasitaemia on antibody responses to single-dose and two-dose HPV vaccination: results from the DoRIS dose-reduction immunogenicity trial in Tanzanian girls.

Vaccine·2026

Same journal

Public health benefits of maternal influenza vaccination among pregnant women and infants <6 months in the United States, 2011-2020.

Vaccine·2026

Same journal

Effectiveness and acceptability of an opt-out nudge to promote influenza vaccination among medical residents: A randomized controlled trial.

Vaccine·2026

See all related articles

Area of Science:

Vaccinology
Public Health
Evidence-Based Medicine

Background:

Vaccines undergo continuous development and review post-licensure.
Manufacturing technology and disease dynamics necessitate ongoing evaluation of vaccine regimens.
Public perception of vaccine safety and effectiveness influences decision-making.

Purpose of the Study:

To define and advocate for Evidence-Based Vaccinology (EBV).
To highlight the critical role of EBV in vaccine lifecycle management.
To emphasize the necessity of rigorous scientific standards in vaccinology.

Main Methods:

Application of Evidence-Based Medicine (EBM) principles in clinical trials and public health programs.
Integration of statistically validated research methods (GLP, GMP, GCRP, GVP).

Related Experiment Videos

Data-driven decision-making by multidisciplinary specialists.

Main Results:

EBV ensures a robust scientific basis for vaccine quality control and efficacy determination.
It facilitates valid assessment of vaccine safety, effectiveness, and cost-benefit ratios.
EBV supports post-licensure safety monitoring and risk:benefit analyses.

Conclusions:

Evidence-Based Vaccinology is essential for maintaining rigorous scientific standards in vaccine development and utilization.
Adherence to EBV principles is crucial for ensuring vaccine quality, safety, and effectiveness.
EBV underpins public confidence in vaccines through transparent, data-driven practices.