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Brain circulation in cerebral transient ischemic attacks.

M Fujishima, K Tanaka, K Fukiyama

    Japanese Heart Journal
    |November 1, 1975
    PubMed
    Summary
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    This study found reduced cranial blood flow and prolonged transit times in patients experiencing transient ischemic attacks (TIA). Cardiac issues like bradycardia may contribute to TIA by lowering brain perfusion.

    Area of Science:

    • Neurology
    • Cardiology
    • Medical Imaging

    Background:

    • Transient ischemic attacks (TIA) are critical indicators of cerebrovascular disease.
    • Understanding the physiological factors contributing to TIA is crucial for prevention and treatment.
    • Cerebral blood flow dynamics are often altered in patients with cerebrovascular conditions.

    Purpose of the Study:

    • To investigate cranial blood flow, mean cranial transit time, and cranial blood volume in patients with TIA.
    • To explore the relationship between heart rate, cardiac dysrhythmias, and cerebral perfusion in TIA patients.
    • To identify potential etiological factors for TIA related to cerebral hemodynamics.

    Main Methods:

    • Intravenous RISA (Radioiodinated Serum Albumin) technique was used for measurements.

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  • Cranial blood flow, mean cranial transit time, and cranial blood volume were assessed in 10 TIA patients.
  • Data were collected at various intervals following the last TIA episode.

    • Main Results:

    • Subnormal cranial blood flow was observed in 5 out of 11 determinations.
    • Mean cranial transit time tended to be prolonged in the affected hemisphere in cases suggesting unilateral lesions.
    • Decreased cranial blood flow correlated with heart rates below 60/min or atrial fibrillation in TIA patients.

    Conclusions:

    • Reduced cerebral perfusion, indicated by subnormal cranial blood flow and prolonged transit times, is associated with TIA.
    • Cardiac dysrhythmias, particularly bradycardia, may precipitate TIA by compromising brain perfusion.
    • Cerebral hemodynamic changes and cardiac factors are significant considerations in the pathophysiology of TIA.