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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
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Is there a relationship between left ventricular systolic function and serum cytokines level in patients with

Katarzyna Mizia-Stec1, Tadeusz Mandecki, Barbara Zahorska-Markiewicz

  • 12nd Department of Cardiology; Silesian University School of Medicine, ul. Ziołowa 45/47, 40-635 Katowice, Poland. biboch@slam.katowice.pl

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
|February 23, 2002
PubMed

Insights

Elevated tumor necrosis factor-alpha (TNFalpha) and interleukin-10 (IL-10) levels are found in patients with coronary artery disease (CAD). Impaired left ventricular (LV) function in CAD patients is associated with higher soluble tumor necrosis factor receptor 1 (sTNFR 1) concentrations.

Area of Science:

  • Cardiovascular Research
  • Immunology
  • Biochemistry

Background:

  • Cytokines are increasingly implicated in the pathogenesis of heart failure and atherosclerosis.
  • Understanding the role of specific inflammatory markers in coronary artery disease (CAD) is crucial for patient management.

Purpose of the Study:

  • To evaluate serum levels of selected cytokines and soluble receptors in patients with CAD.
  • To investigate the relationship between these marker concentrations and left ventricular (LV) systolic function.

Main Methods:

  • Serum levels of TNFalpha, sTNFR 1 and 2, IL-2, and IL-10 were measured in 100 CAD patients and 20 healthy controls.
  • Patients were categorized based on LV regional wall motion disturbances or normal LV function.

Main Results:

  • Significantly higher serum TNFalpha and IL-10 concentrations were observed in CAD patients compared to controls.
  • CAD patients with LV regional wall motion disturbances showed elevated sTNFR 1 levels.
  • LV ejection fraction and motion score index correlated with TNFalpha and sTNFR 1 levels in patients with CAD.

Conclusions:

  • Increased serum concentrations of TNFalpha and IL-10 are present in patients with CAD.
  • Elevated sTNFR 1 levels are associated with impaired LV contractility in these patients.
  • Serum cytokine activation may contribute to the development of heart failure in individuals with CAD.
Abstract

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