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Cytotoxic coumaronochromones from the roots of Euchresta formosana
Wen-Li Lo1, Fang-Rong Chang, Chih-Chuang Liaw
1Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan.
Planta Medica
|February 23, 2002
Abstract:
Five new coumaronochromones, euchretins J-N (1 - 5), along with twelve known compounds, euchretins A (6), C, D, F, H, I, (+)-matrine, (-)-cytisine, quercetin, trifolirhizin, retusin 8-methyl ether, and genistein, were isolated from the methanolic extracts of Euchresta formosana. The structures of compounds 1 - 5 were established by spectroscopic analyses. Among them, compounds 1, 4 and 6 were demonstrated to have cytotoxicity against 59T cell line, and compound 1 was also found to be active against SCM-1 cell line.