Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cholinergic and noncholinergic septal neurons modulate strategy selection in spatial learning.

J F Cahill1, M G Baxter

  • 1Department of Psychology, Harvard University, 906 William James Hall, 33 Kirkland Street, Cambridge, MA 02138, USA.

The European Journal of Neuroscience
|February 28, 2002
PubMed
Summary

The medial septum/vertical limb of the diagonal band (MS/VDB) modulates hippocampal place learning in rats. However, its cholinergic neurons are not essential for spatial discrimination tasks.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Brain Charts for the Rhesus Macaque Lifespan.

bioRxiv : the preprint server for biology·2024
Same author

Persistent alteration in behavioural reactivity to a mild social stressor in rhesus monkeys repeatedly exposed to sevoflurane in infancy.

British journal of anaesthesia·2018
Same author

Visual recognition memory is impaired in rhesus monkeys repeatedly exposed to sevoflurane in infancy.

British journal of anaesthesia·2017
Same author

Characterization of core-shell MOF particles by depth profiling experiments using on-line single particle mass spectrometry.

The Analyst·2015
Same author

Contrasting impacts of defoliation on root colonization by arbuscular mycorrhizal and dark septate endophytic fungi of Medicago sativa.

Mycorrhiza·2013
Same author

Regional boreal biodiversity peaks at intermediate human disturbance.

Nature communications·2012

Area of Science:

  • Neuroscience
  • Behavioral Neuroscience
  • Cognitive Neuroscience

Background:

  • The hippocampus is crucial for spatial learning and navigation.
  • Rats typically use place-learning strategies, then switch to motor response strategies in spatial tasks.
  • The medial septum/vertical limb of the diagonal band (MS/VDB) projects to the hippocampus and influences learning.

Purpose of the Study:

  • To investigate the role of the MS/VDB and its cholinergic projections in spatial discrimination learning in rats.
  • To determine if cholinergic MS/VDB neurons are necessary for place-learning strategies.

Main Methods:

  • Rats were trained on a spatial discrimination task in a plus maze.
  • Lesions of the MS/VDB were induced using 192 IgG-saporin (cholinergic-sparing) or ibotenic acid (non-selective).

Related Experiment Videos

  • Behavioral strategies (place vs. response learning) and acquisition rates were assessed.

    • Main Results:

    • Rats with cholinergic-sparing MS/VDB lesions showed facilitated spatial discrimination acquisition and normal strategy switching.
    • Rats with non-selective MS/VDB lesions were impaired in acquisition and strategy use.
    • Hippocampal place-learning strategies were modulated by the MS/VDB, but not solely dependent on its cholinergic neurons.

    Conclusions:

    • The MS/VDB plays a modulatory role in hippocampal-dependent place learning.
    • Cholinergic MS/VDB neurons are not strictly necessary or sufficient for employing place strategies in this spatial task.
    • Non-cholinergic MS/VDB projections may be involved in modulating spatial learning strategies.