Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cerebellar contribution to spatial event processing: involvement in procedural and working memory components.

L Mandolesi1, M G Leggio, A Graziano

  • 1Department of Psychology, University of Rome La Sapienza, Via dei Marsi 78, 00185 Rome, Italy.

The European Journal of Neuroscience
|February 28, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The evolution to hepta-refractory myeloma involves sequential loss of CD38, BCMA and GPRC5D.

Leukemia·2026
Same author

Utility of routine preoperative laboratory testing for patients undergoing minor gynaecologic surgical procedures: interim analysis of their impact on intraoperative and postoperative complications.

Facts, views & vision in ObGyn·2024
Same author

Visuospatial working memory abilities in children analyzed by the bricks game task (BGT).

Psychological research·2023
Same author

Cerebellar engagement in the attachment behavioral system.

Scientific reports·2022
Same author

Effectiveness of topical α-Tocopherol Acetate in burn infection treatment.

Annals of burns and fire disasters·2020
Same author

Systemic Immunosuppression Is Highly Effective in the Long-term Control of Inflammatory non-infectious Uveitic Choroidal Neovascularization: A Comparative Study.

Ocular immunology and inflammation·2020
Same journal

Improved Motor Neuron Preservation and Axonal Recovery Following Experimental Sciatic Nerve Repair With Heterologous Fibrin Biopolymer.

The European journal of neuroscience·2026
Same journal

Topography of Regional Cerebral GABA<sub>A</sub> Receptor Availability in Parkinson's Disease Patients With Freezing of Gait.

The European journal of neuroscience·2026
Same journal

Enhanced Time-Locked Decoding for Spoken Words but Not Environmental Sounds in Natural-Like Auditory Conditions.

The European journal of neuroscience·2026
Same journal

Learning Dynamics in Biophysical Spiking Network Models Are Shaped by KCC2/NKCC1 Cotransporter Stoichiometry.

The European journal of neuroscience·2026
Same journal

Dopamine Receptor Agonism in the Nucleus Accumbens Shell During Aversive Learning or Memory Retrieval: Differential Effects Depending on the Degree of Sugar Familiarity.

The European journal of neuroscience·2026
Same journal

Training in the Categorization of Aerial and Terrestrial Scenes Differentially Impacts Scene-Selective and Nonscene-Selective Regions in Occipitotemporal Cortex.

The European journal of neuroscience·2026
See all related articles

Cerebellar lesions impair spatial learning and working memory. Damage to the cerebellum causes inflexible procedural use and severe deficits in acquiring new spatial behaviors.

Area of Science:

  • Neuroscience
  • Cognitive Science
  • Behavioral Neuroscience

Background:

  • Cerebellar lesions are known to affect spatial cognition.
  • The specific roles of the cerebellum in spatial procedural and working memory remain incompletely understood.

Purpose of the Study:

  • To investigate the cerebellum's contribution to acquiring spatial procedural and working memory.
  • To determine if cerebellar lesions cause deficits in radial maze task performance.

Main Methods:

  • Radial maze tasks were employed with different experimental groups: hemicerebellectomized (HCbed) rats and controls, with and without pretraining.
  • A forced-choice paradigm was used to differentiate procedural from working memory components.

Main Results:

Related Experiment Videos

  • Non-pretrained HCbed rats showed impairments in motor, spatial, and procedural aspects.
  • Pretrained HCbed rats performed similarly to controls on spatial and procedural tasks but worsened significantly when forced to rely solely on working memory.
  • Non-pretrained HCbed rats exhibited perseverative tendencies, indicating difficulty in acquiring and modifying behaviors.

Conclusions:

  • Cerebellar damage results in inflexible procedural use and significant impairment of working memory processes in spatial tasks.
  • The cerebellum plays a crucial role in the acquisition and contextual modification of new spatial behaviors.