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[An genetic epidemiology study of MTHFR gene and blood level (sibpair linkage analysis)]
Objective:
To explore the relationship between MTHFR gene and blood pressure.
Methods:
A total of 142 sibpairs were collected from rural communities of CCPACH. MTHFR gene genotypes were determined by an assay based on the polymerase chain reaction. Phenotype of this study was the level of blood pressure. Covariates were measured by questionnaire, physical examination and clinical indices. Sibpair linkage analysis was used to analyse data by SAGE software.
Results:
In this study, prevalence of TT genotype of MTHFR gene was 9.3%, while CT was 41%. There was no evidence for linkage of the MTHFR gene with either systolic or diastolic blood pressure identified.
Conclusion:
In our study population, MTHFR gene did not seem to be not related to blood pressure.