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[The relationship between polymorphism of angiotensinogen gene and essential hypertension]
1The Institute of Preventive Medicine, Shanghai Medical University, Shanghai 200032, China.
Objective:
To study the renin-angiotensin system (RAS) involvement in the hormonal regulation of BP and blood volume and the relationship between angiotensinogen (AGT) was the sole preliminary acting materials in the RAS.
Method:
Population-based case-control study was conducted using PCR-RFLP techniques to explore the relationship between the M235T polymorphism of AGT and EH in Wangxin township, Jiading District of Shanghai.
Results:
The frequency of TT genotype in EH cases was significantly higher than in controls (42.8% and 33.0%). The odds ratio (OR) for those exposed to TT genotype was 3.61, comparing with MM genotype. It was suggested that TT genotype be the susceptible genotype of EH in Wangxin. The frequency of allele T in EH cases was 73.89%, significantly higher than that of 60.31% in controls. With the increase of allele T, the risk of EH also increased (P < 0.05). In EH cases, the BMI increased in the order of MM, MT and TT, and significant differences between the groups were observed.
Conclusion:
TT genotype is the susceptible genotype of EH in Wangxin.