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[The study of countermeasures on measles control in infants]
1Senitation and Anti-epidemic Station of Jilin Province. Changchun 130021, China.
Insights
Maternal measles antibody levels are low, impacting newborns. Early infant vaccination at six months may improve protection against measles, reducing illness in infants.
Area of Science:
- Immunology
- Pediatrics
- Vaccinology
Context:
- Maternal antibody transfer is crucial for infant immunity.
- Measles antibody levels in mothers and newborns are often insufficient for sustained protection.
- Infant vaccination schedules aim to establish protective immunity before maternal antibodies wane.
Purpose:
- To assess measles IgG antibody levels in mothers and newborns.
- To evaluate the correlation between maternal and infant measles antibody titers.
- To determine the efficacy of current infant measles vaccination schedules at 6 and 8 months.
- To inform measles control strategies for infants.
Summary:
- Measles IgG antibody levels were measured in 58 mother-newborn pairs using ELISA.
- Newborns showed low initial measles antibody levels that declined significantly by 3, 6, and 8 months.
- Vaccination success rates and antibody distribution were similar in 6- and 8-month-old infants, but overall antibody levels remained low, offering minimal protection.
- Maternal measles antibody levels were generally low, correlating with infant levels.
Impact:
- Low maternal antibody levels necessitate improved infant immunization strategies.
- Vaccinating mothers may enhance neonatal measles antibody levels.
- Shifting the primary measles vaccination age to 6 months could reduce infant measles morbidity in specific regions.
Objective:
To understand: a) measles antibody levels in purpura and their newborns, and the relation between them, b) maternal transferred measles antibody level of different age group infants, c) immunization rates of success in 6 and 8 month old infants, d) to study measles control countermeasures on infants.
Method:
To test measles IgG antibody levels of infant's blood using ELISA method.
Results:
Antibody levels of measles in 58 pairs of mother and their newborns, 51 pairs were the same, while 7 pairs were different. Measles antibody levels in newborns was not high and reduced to 50% in 3 months, 20% in 6 months, and 15% in 8 months. The antibody levels in 6 and 8 month olds were low, nearly no protection to children. It was found that rates of immunization success and the antibody distribution were not statistically different between 6 and 8 months olds after measles vaccination.
Conclusion:
It was found that the measles antibody level in most matured women was low. Since mother's measles antibody level has close relation to their newborns, it seems that the newborn's antibody level can be improved by vaccination to matured women. In order to reduce morbidity of infant measles, the age of first vaccination of measles vaccine should be changed from 8 months old to 6 months old in some regions.