Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Activity-dependent mapping in the retinotectal projection.

Elizabeth A Debski1, Hollis T Cline

  • 1Department of Biological Sciences, University of Kentucky, 101 Morgan Biological Science Building, Lexington, Kentucky 40506, USA.

Current Opinion in Neurobiology
|February 28, 2002
PubMed
Summary

N-methyl-d-aspartate receptor activity is crucial for retinotectal map refinement. New research reveals nitric oxide, brain-derived neurotrophic factor, serotonin, and acetylcholine also play key roles in visual system development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Atypical Tetracyclines Promote Longevity and Ferroptotic Neuroprotection via Translation Attenuation.

Aging cell·2026
Same author

Atypical tetracyclines promote longevity and ferroptotic neuroprotection via translation attenuation.

bioRxiv : the preprint server for biology·2026
Same author

Microglia-to-neuron signaling links <i>APOE4</i> and inflammation to enhanced neuronal lipid metabolism and network activity.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Intravitreal NHS-Biotin Injection and Immunohistochemistry to Label and Image Protein Transport in the Mouse Optic Nerve.

Bio-protocol·2025
Same author

Activity-dependent synthesis of Emerin gates neuronal plasticity by regulating proteostasis.

Cell reports·2025
Same author

Adeno-associated viral tools to trace neural development and connectivity across amphibians.

Developmental cell·2024

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Visual System Research

Background:

  • The N-methyl-d-aspartate (NMDA) receptor's role in retinotectal map organization was discovered 15 years ago.
  • Activity-dependent mechanisms are fundamental to neural development.
  • Understanding these mechanisms is key to visual system function.

Purpose of the Study:

  • To identify additional signaling pathway components involved in activity-dependent retinotectal map formation and maintenance.
  • To explore the intersection of retinotectal mapping with other visual system development processes.

Main Methods:

  • Review of recent studies identifying signaling molecules.
  • Analysis of candidate retrograde messengers (nitric oxide, brain-derived neurotrophic factor).

Related Experiment Videos

  • Investigation of neuronal excitability modulators (serotonin, acetylcholine) in mapping.

    • Main Results:

    • Nitric oxide and brain-derived neurotrophic factor are identified as potential retrograde messengers influencing map formation.
    • Serotonin and acetylcholine modulate neuronal excitability and impact retinotectal mapping.
    • The mapping process is shown to interact with process outgrowth, synaptic turnover, and neuromodulation.

    Conclusions:

    • Multiple signaling pathways and molecules contribute to retinotectal map refinement.
    • Activity-dependent mapping is integrated with broader visual system development processes.
    • Further research is needed to fully elucidate these complex interactions.