Terminal deoxynucleotidyl transferase activity and B cell markers in chronic myelogenous leukemia blast crisis

High terminal deoxynucleotidyl transferase activities were found in blast cells having B cell markers in 3 patients suffering from chronic myelogenous leukemia. The blast cells from these patients were lymphoblastic in appearance. Two of these cases were treated with vincristine and prednisolone. They responded well to this therapy.