Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The KSHV latency-associated nuclear antigen: a multifunctional protein.

Takashi Komatsu1, Mary E Ballestas, Andrew J Barbera

  • 1Department of Medicine, Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Ave., Boston, MA 021115, USA.

Frontiers in Bioscience : a Journal and Virtual Library
|February 28, 2002
PubMed
Summary

Kaposi

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cuboid height measured using ultrasound is related to sex and dorsal arch height.

Scientific reports·2026
Same author

Host microRNA-31-5p regulates KHDRBS3 expression and modulates viral gene expression during KSHV lytic reactivation.

Cell reports·2026
Same author

Development of a Lateral Longitudinal Arch Evaluation Method for the Foot Using Ultrasonography: Validation With Radiography and Verification of Intrarater and Interrater Reliability.

Journal of foot and ankle research·2025
Same author

Host microRNA-31-5p represses oncogenic herpesvirus lytic reactivation by restricting the RNA-binding protein KHDRBS3-mediated viral gene expression.

bioRxiv : the preprint server for biology·2025
Same author

Consensus Definitions of Cytomegalovirus (CMV) Infection and Disease in Transplant Patients Including Resistant and Refractory CMV for Use in Clinical Trials: 2024 Update From the Transplant Associated Virus Infections Forum.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2024
Same author

Kaposi's sarcoma herpesvirus latency-associated nuclear antigen broadly regulates viral gene expression and is essential for lytic infection.

PLoS pathogens·2024

Area of Science:

  • Virology
  • Oncology
  • Molecular Biology

Background:

  • Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is linked to aggressive lymphoproliferative disorders like Kaposi's sarcoma and primary effusion lymphoma.
  • In KSHV-infected tumor cells, viral genes are expressed during latency, with latency-associated nuclear antigen (LANA1) being consistently and highly expressed.

Purpose of the Study:

  • To review the multifaceted roles of LANA1 (latency-associated nuclear antigen 1) in the context of KSHV infection.

Main Methods:

  • Review of existing literature and in situ hybridization and immunohistochemistry data.
  • Analysis of LANA1's functions in viral episome persistence, transcriptional regulation, and cellular protein interactions.

Main Results:

Related Experiment Videos

  • LANA1 is the sole protein consistently and highly expressed in latently KSHV-infected tumor cells.
  • Multiple functions of LANA1 in KSHV infection have been identified and are discussed.

Conclusions:

  • LANA1 plays critical roles in KSHV infection, including maintaining viral episomes, regulating gene expression, and interacting with host cellular proteins.
  • Understanding LANA1's functions is key to comprehending KSHV pathogenesis and developing therapeutic strategies.