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Related Experiment Videos

Herpes simplex virus.

Travis J Taylor1, Mark A Brockman, Elizabeth E McNamee

  • 1Harvard Medical School, Department of Microbiology and Molecular Genetics, 200 Longwood Avenue, Boston, MA 02115, USA.

Frontiers in Bioscience : a Journal and Virtual Library
|February 28, 2002
PubMed
Summary
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Corrigendum to "Herpes simplex virus 1 ICP34.5 acts to maintain latency in human and mouse neurons" [Virology 611 (2025) 110652].

Virology·2025

Herpes simplex virus (HSV) causes orofacial and genital infections. Understanding its productive and latent stages is key to developing new antiviral therapies and vaccines.

Area of Science:

  • Virology
  • Molecular Biology
  • Cell Biology

Background:

  • Herpes simplex virus (HSV) causes common human infections, primarily HSV-1 in the orofacial region and HSV-2 in the genital region.
  • HSV infection involves a productive phase in mucosal epithelial cells and a subsequent latent phase within sensory neurons.
  • Understanding the distinct viral gene expression patterns during productive (high expression) and latent (low/no expression) infection is crucial.

Purpose of the Study:

  • To provide an introduction to the biology of herpes simplex virus (HSV).
  • To detail the key aspects of the HSV infection cycle, including productive and latent stages.
  • To highlight the significance of HSV research in advancing our understanding of eukaryotic cell processes.

Main Methods:

Related Experiment Videos

  • This review synthesizes current knowledge on HSV biology and infection.
  • It examines viral interactions with host cell functions in both epithelial and neuronal cells.
  • The review focuses on the differences in viral gene product expression during productive and latent phases.

    • Main Results:

    • HSV infection progresses through distinct productive and latent phases with differential viral gene expression.
    • HSV significantly interacts with and modifies numerous host cell functions.
    • Research into HSV has expanded fundamental knowledge of eukaryotic cell biology.

    Conclusions:

    • A comprehensive understanding of HSV's productive and latent infection cycles is essential.
    • This knowledge is critical for designing novel antiviral agents and vaccines.
    • Continued research on HSV contributes significantly to basic cell and molecular biology.