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Comparative analysis of the human dystrophin and utrophin gene structures
Uberto Pozzoli1, Manuela Sironi, Rachele Cagliani
1IRCCS E. Medea, Associazione La Nostra Famiglia, 23842 Bosisio Parini, LC, Italy. msironi@bp.lnf.it
Genetics
|February 28, 2002
Abstract:
We present analysis of intronic sequences in the human DMD and UTRN genes. In both genes accumulation of repeated elements could account for intron expansion. Out-of-frame rod-domain exons have stronger splice sites and are separated by significantly longer introns as compared to in-frame exons. These features are unique for the two homologs and not shared by other spectrin superfamily genes.