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Published on: September 25, 2013
Caenorhabditis elegans unc-37/groucho interacts genetically with components of the transcriptional mediator complex
1Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Abstract:
Groucho functions as a general corepressor by modulating chromatin structure and has a widespread role in many developmental processes. Here we show that Groucho may also interact with the basal transcriptional machinery. Mutations in Caenorhabditis elegans groucho interact with mutations in components of the transcriptional Mediator complex, resulting in synthetic lethality and loss of male sensory neurons.
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