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Prolonged jaundice following percutaneous coronary intervention and ticlopidine therapy

P T Tsui1, S T Lai, W S Leung

  • 1Department of Medicine and Geriatrics, Princess Margaret Hospital, 2-10 Princess Margaret Hospital Road, Laichikok, Hong Kong.

Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi
|February 28, 2002
PubMed

Insights

Ticlopidine can cause serious cholestatic hepatitis. Clopidogrel offers a safe alternative for patients with a history of ticlopidine-induced liver injury, preventing stent thrombosis.

Area of Science:

  • Cardiology
  • Hepatology
  • Pharmacology

Background:

  • Ticlopidine, an adenosine diphosphate receptor blocker, is crucial for preventing stent thrombosis post-percutaneous coronary intervention.
  • Serious adverse effects of ticlopidine include neutropenia, thrombotic thrombocytopenic purpura, and cholestatic hepatitis.

Observation:

  • This report details four cases of prolonged jaundice following ticlopidine treatment, including a fatal outcome.
  • The study highlights the potential severity of ticlopidine-induced cholestatic hepatitis.

Findings:

  • Alternative antithrombotic strategies were employed for subsequent percutaneous coronary interventions.
  • Clopidogrel demonstrated safety and efficacy in two patients previously experiencing ticlopidine-related cholestatic hepatitis.

Implications:

  • These findings underscore the importance of monitoring for liver injury during ticlopidine therapy.
  • Clopidogrel emerges as a viable and safe alternative for patients with a history of ticlopidine-induced hepatotoxicity, ensuring continued protection against stent thrombosis.

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