Linking molecular and bedside research: designing a clinical research infrastructure

Area of Science:

• Clinical Research
• Translational Science
• Genomics

Background:

• General Clinical Research Centers (GCRCs) have been instrumental in academic medical centers for four decades.
• GCRCs link molecular and clinical research to understand human disease mechanisms.
• The program fosters deeper understanding of human biology and improved global health.

Purpose of the Study:

• To highlight the historical significance and ongoing importance of GCRCs.
• To advocate for the evolution of GCRCs to leverage advancements like the Human Genome Project.
• To propose GCRCs as a model for international patient-oriented research infrastructure.

Main Methods:

• The abstract discusses the role and impact of GCRCs based on their 40-year history.
• It emphasizes the need for GCRCs to adapt and integrate new scientific opportunities.
• The text suggests a framework for GCRC program development, including educational and quality control components.

Main Results:

• GCRCs have facilitated significant patient-oriented research achievements.
• A well-structured GCRC program enhances training in research ethics, design, and technology.
• The Human Genome Project presents new opportunities that GCRCs can harness.

Conclusions:

• GCRCs are vital for advancing patient-oriented research and understanding human disease.
• A modernized GCRC program, embracing multicentric and community-based approaches, is essential.
• GCRCs can serve as the clinical interface for the Human Genome Project, translating genetic discoveries into health benefits.