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Progesterone receptor status of breast cancer metastases
M Branković-Magić1, R Janković, Z Nesković-Konstantinović
1Institute for Oncology and Radiology of Serbia, Pasterova 14, 11000 Belgrade, Yugoslavia. magicm@drenik.net
Purpose:
The usefulness of steroid receptor content in breast cancer metastases for metastatic disease therapy planning was examined in this study.
Methods:
Steroid receptors in primary tumors and corresponding metastases in the same breast cancer patients ( n=23) were determined by five-point DCC assay. We carried out an analysis of the therapeutic response and comparison of the progression-free interval of patients treated with endocrine/chemo-endocrine therapy for metastatic disease according to the positive/negative progesterone receptor status of primary tumors, or of breast cancer metastases.
Results And Conclusions:
It seems that the lack of positive progesterone receptors in metastasis (0/8) and conversion from PR+ primary to PR- metastasis (5/8) may be important in describing the non-responder phenotype. We obtained a similar progression-free interval in patients with progesterone receptor-positive/negative primary tumors, but a longer progression-free interval in the patients with progesterone receptor-positive metastases ( n=9) than with negative ones ( n=14), indicating the possibility of using steroid receptor content from metastases for metastatic disease therapy planning.