Related Experiment Video

Updated: Oct 2, 2026

A New Murine Model of Endovascular Aortic Aneurysm Repair
08:51

A New Murine Model of Endovascular Aortic Aneurysm Repair

Published on: July 7, 2013

Proteolysis of the abdominal aortic aneurysm wall and the association with rupture

E Petersen1, F Wågberg, K A Angquist

  • 1Department of Surgery, Umeå University Hospital, Umeå, Sweden.

European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery
|February 28, 2002
PubMed
Abstract

Insights

Abdominal aortic aneurysm (AAA) rupture is linked to increased matrix metalloproteinase-9 (MMP-9) levels. While MMP-2 correlates with AAA expansion, MMP-9 may drive progression toward rupture.

Area of Science:

  • Vascular biology and pathology
  • Biochemistry of extracellular matrix degradation

Background:

  • Abdominal aortic aneurysms (AAAs) are life-threatening vascular diseases.
  • Proteolysis of the AAA wall is implicated in aneurysm expansion and rupture.

Purpose of the Study:

  • To investigate proteolysis in the abdominal aortic aneurysm (AAA) wall.
  • To determine the association between specific proteases and AAA rupture.

Main Methods:

  • Quantified matrix metalloproteinases (MMP-2, MMP-9) and tissue inhibitors of metalloproteinases (TIMP-1, TIMP-2) in AAA tissue.
  • Compared enzyme levels between ruptured AAA (rAAA) and asymptomatic AAA (aAAA) based on diameter.

Main Results:

  • MMP-9 levels were significantly higher in medium-sized rAAA compared to large asymptomatic AAA.
  • MMP-2 levels were significantly higher in large asymptomatic AAA compared to medium-sized rAAA.
  • MMP-2 correlated positively with AAA diameter, while MMP-9 correlated negatively.

Conclusions:

  • AAA rupture is associated with elevated MMP-9 levels.
  • MMP-9 may contribute to AAA rupture progression, whereas MMP-2 may be involved in aneurysm expansion.
  • TIMP-1 and TIMP-2 levels showed no association with AAA rupture or size.

More Related Videos

Reliable Creation of a Murine Abdominal Aortic Aneurysm Model Using Elastin Sensitization and Perivascular Elastase08:54

Reliable Creation of a Murine Abdominal Aortic Aneurysm Model Using Elastin Sensitization and Perivascular Elastase

Published on: June 26, 2026

Advanced Abdominal Aortic Aneurysm Modeling in Mice by Combination of Topical Elastase and Oral ß-aminopropionitrile07:42

Advanced Abdominal Aortic Aneurysm Modeling in Mice by Combination of Topical Elastase and Oral ß-aminopropionitrile

Published on: July 26, 2024

Related Concept Videos

Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
Aneurysm I: Introduction01:30

Aneurysm I: Introduction

An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...