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Related Experiment Videos

Delirium predicts 12-month mortality.

Jane McCusker1, Martin Cole, Michal Abrahamowicz

  • 1Department of Clinical Epidemiology and Community Studies, St Mary's Hospital Center, 3830 Lacombe Ave, Room 2508, Montreal, Quebec, Canada H3T 1M5. jane.mccusker@mcgill.qc.ca

Archives of Internal Medicine
|February 28, 2002
PubMed
Summary

Delirium independently predicts increased 12-month mortality in older medical patients. This risk is higher for patients without dementia, with greater symptom severity indicating worse outcomes.

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Area of Science:

  • Geriatric Medicine
  • Critical Care Medicine
  • Neuroscience

Background:

  • Previous studies on delirium and mortality had limitations like small sample sizes.
  • Delirium's independent impact on post-discharge mortality requires further investigation.
  • This study addresses confounding factors in older medical inpatients.

Purpose of the Study:

  • To determine the independent effect of delirium on 12-month mortality in older medical inpatients.
  • To investigate the influence of delirium type (incident vs. prevalent) and symptom severity on mortality.
  • To assess the interaction between delirium and dementia on mortality risk.

Main Methods:

  • Prospective, observational study of two cohorts: patients with delirium (n=243) and controls without delirium (n=118).

Related Experiment Videos

  • Inclusion criteria: medical inpatients aged 65 years or older.
  • Statistical analysis using Cox proportional hazards model with covariate adjustment for mortality prediction.

    • Main Results:

    • Delirium was an independent predictor of 12-month mortality (adjusted hazard ratio: 2.11).
    • The association between delirium and mortality persisted throughout the 12-month period.
    • Mortality risk was significantly higher in patients with delirium and without dementia, particularly with greater symptom severity.

    Conclusions:

    • Delirium is a significant independent prognostic marker for increased 12-month mortality in older medical inpatients.
    • Delirium's prognostic value is particularly pronounced in patients without co-existing dementia.
    • Severity of delirium symptoms is associated with mortality risk, especially in non-demented patients.