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Invasive candidosis in pediatric patients
Emmanuel Roilides1, Isaac Kadiltsoglou, Dimitrios Zahides
13rd Department of Pediatrics, University of Thessaloniki, and.
Summary
Invasive Candida infections are common in pediatric patients, particularly premature neonates, leading to increased mortality. Early diagnosis and treatment of invasive candidosis significantly improve patient outcomes.
Area of Science:
- Pediatric Infectious Diseases
- Mycology
- Clinical Microbiology
Background:
- Invasive candidosis poses a significant threat to pediatric patients, especially neonates.
- Understanding the epidemiology and outcomes of invasive fungal infections is crucial for improving patient care.
Purpose of the Study:
- To analyze the incidence and outcomes of invasive Candida infections in pediatric patients.
- To identify risk factors and common Candida species associated with invasive infections in children.
Main Methods:
- An observational prospective study was conducted from December 1993 to July 1995.
- Microbiologically documented cases of invasive candidosis in neonates, infants, and children were analyzed.
- Data on patient demographics, clinical presentation, causative species, and treatment outcomes were collected.
Main Results:
- Thirty-nine cases of invasive candidosis occurred in 38 pediatric patients, with 54% in neonates.
- The incidence was significantly higher in neonatal departments compared to other pediatric units.
- Candida albicans was the most common species, but non-albicans species showed higher azole resistance. Mortality was 34%, particularly in candidemic patients.
Conclusions:
- Invasive candidosis is a frequent and serious infection in pediatric patients, especially premature neonates.
- Prompt diagnosis and antifungal therapy are critical for favorable outcomes.
- Non-albicans Candida species present a growing challenge due to potential antifungal resistance.