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Low dietary magnesium increases supraventricular ectopy.

Leslie M Klevay1, David B Milne

  • 1US Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, ND 58202-9034, USA. lklevay@gfhnrc.ars.usda.gov

The American Journal of Clinical Nutrition
|February 28, 2002
PubMed
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Low dietary magnesium intake in postmenopausal women led to depletion, evidenced by lower magnesium levels and increased heart arrhythmias. The recommended daily allowance of 320 mg appears adequate, while 130 mg is insufficient.

Area of Science:

  • Cardiovascular Health
  • Nutritional Science
  • Electrophysiology

Background:

  • Magnesium plays a role in preventing ischemic heart disease, including arrhythmias and sudden death.
  • Understanding magnesium's impact on cardiovascular health is crucial for disease prevention.

Purpose of the Study:

  • To test if magnesium intake below the recommended dietary allowance (RDA) causes biochemical and physiological depletion.
  • To establish magnesium requirements using biochemical and electrophysiological markers.

Main Methods:

  • A double-blind, crossover study with 22 postmenopausal women.
  • Diets provided either less than half or more than the RDA (320 mg/d) of magnesium.
  • Magnesium levels were measured in blood and urine; Holter electrocardiograms monitored heart activity.

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Main Results:

  • Lower dietary magnesium significantly decreased magnesium concentrations in erythrocytes, serum, and urine.
  • Low magnesium intake correlated with a significant increase in supraventricular and ventricular ectopic beats.
  • No instances of hypomagnesemia, hypocalcemia, or hypokalemia were observed.

Conclusions:

  • The study defined magnesium requirements using biochemical and electrophysiological data.
  • The RDA of 320 mg/d is supported, while 130 mg/d is inadequate.
  • Individuals in soft water areas, using diuretics, or prone to magnesium loss may need higher magnesium intake.