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Potential of rifamides to inhibit TNF-induced NF-kappaB activation
Ali A Pahlevan1, David J M Wright, Laura Bradley
1Infectious Diseases and Microbiology, Charing Cross Campus, Imperial College, London, UK.
The Journal of Antimicrobial Chemotherapy
|February 28, 2002
Abstract:
Rifamides are important components in the treatment of tuberculosis. However, it is well documented that these drugs can have immunosuppressive activity, a property of these drugs that is particularly relevant to AIDS patients. In this study, we have shown that a number of rifamide analogues have the potential to block tumour necrosis factor (TNF)- or phorbol myristate acetate-induced NF-kappaB activation. As TNF is important in the host defence against tuberculosis, suppression of this activity may provide a potential mechanism of rifamide immunosuppressive activity.