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Related Experiment Videos

Complement activation in postpartum thyroiditis.

O E Okosieme1, A B Parkes, B McCullough

  • 1Department of Medicine, University of Wales College of Medicine, Cardiff, UK.

QJM : Monthly Journal of the Association of Physicians
|February 28, 2002
PubMed
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Postpartum thyroid dysfunction (PPTD) involves thyroid peroxidase autoantibodies (TPOAb). However, complement activation, despite bioactive TPOAb, appears minimal and may not be a key factor in PPTD development.

Area of Science:

  • Endocrinology
  • Immunology
  • Reproductive Medicine

Background:

  • Postpartum thyroid dysfunction (PPTD) affects 50% of pregnant women with elevated thyroid peroxidase autoantibodies (TPOAb).
  • The role of complement activation in PPTD pathogenesis is currently unknown, despite in vitro evidence of TPOAb activating complement.

Purpose of the Study:

  • To investigate complement system activation in women experiencing postpartum thyroiditis.
  • To determine if complement activation contributes to the development of PPTD.

Main Methods:

  • Weekly monitoring of complement activation in 24 postpartum women with raised TPOAb.
  • ELISA assays to measure in-vitro complement C3 activation by TPOAb and serum terminal complement complexes (TCC).

Main Results:

Related Experiment Videos

  • Women who developed PPTD exhibited higher levels of bioactive TPOAb activity.
  • Circulating terminal complement complexes (TCC) remained undetectable in serum throughout the study period.

Conclusions:

  • Despite the presence of bioactive TPOAbs in PPTD, complement activation is insufficient to increase peripheral blood TCC.
  • The complement system likely does not play a significant role in the pathogenesis of postpartum thyroid dysfunction.