Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Adult Stem Cells

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...

Renewal of Intestinal Stem Cells

Renewal of Intestinal Stem Cells

The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...

Histology of the Small Intestine

Histology of the Small Intestine

The small intestine exhibits a unique histological structure that significantly enhances its function in digestion and nutrient absorption. These structures include circular folds, villi, and various specialized cells that collectively facilitate the digestion of food.
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Peptidergic regulation of expression of cellular aging marker proteins in buccal epithelium.]

Advances in gerontology = Uspekhi gerontologii·2025

Same author

Conformational Changes in DNA and Protein Biomolecules in Pathogenesis of Ischemic Stroke.

Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections·2024

Same author

Effect of Collagen and GelMA on Preservation of the Costal Chondrocytes' Phenotype in a Scaffold <i>in vivo</i>.

Sovremennye tekhnologii v meditsine·2023

Same author

Photodynamic Therapy of Melanoma B16 with Chlorin E6 Conjugated with a PSMA-Ligand.

Bulletin of experimental biology and medicine·2021

Same author

[The study of interaction of different forms of human recombinant anti-mullerian hormone with a chimeric analogue of the AMH type II].

Biomeditsinskaia khimiia·2021

Same author

Results and Prospects of Using Activator of Hematopoietic Stem Cell Differentiation in Complex Therapy for Patients with COVID-19.

Stem cell reviews and reports·2021

Search research articles

Related Experiment Video

Updated: Jul 12, 2026

Improved Swiss-rolling Technique for Intestinal Tissue Preparation for Immunohistochemical and Immunofluorescent Analyses

Improved Swiss-rolling Technique for Intestinal Tissue Preparation for Immunohistochemical and Immunofluorescent Analyses

Published on: July 13, 2016

Age-specific ultrastructural postradiation changes in intestinal endocrine cells.

E A Odintsova¹, I M Kvetnoi, A V Trofimov

¹Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk.

Bulletin of Experimental Biology and Medicine

|February 28, 2002

Summary

Radiation exposure causes lasting damage to rat duodenal endocrine cells (apudocytes). Cell disorganization varied by cell type and time post-irradiation, with degranulation dominating hormone release later on.

More Related Videos

Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis

Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis

Published on: May 12, 2019

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation

Published on: July 27, 2022

Related Experiment Videos

Last Updated: Jul 12, 2026

Improved Swiss-rolling Technique for Intestinal Tissue Preparation for Immunohistochemical and Immunofluorescent Analyses

Improved Swiss-rolling Technique for Intestinal Tissue Preparation for Immunohistochemical and Immunofluorescent Analyses

Published on: July 13, 2016

Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis

Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis

Published on: May 12, 2019

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation

Published on: July 27, 2022

Area of Science:

Cell Biology
Radiation Oncology
Gastroenterology

Background:

The gastrointestinal tract's endocrine system plays a crucial role in regulating physiological functions.
Understanding the long-term effects of radiation on these cells is vital for managing patients undergoing radiotherapy.

Purpose of the Study:

To investigate age-specific ultrastructural changes in rat duodenal endocrine cells (apudocytes) following radiation exposure.
To determine the impact of radiation dose and time post-irradiation on apudocyte morphology and function.

Main Methods:

Rats were subjected to single whole-body irradiation at doses of 7 and 7.5 Gy.
Ultrastructural analysis of duodenal endocrine cells was performed at 6 and 12 months post-irradiation.

Main Results:

Significant ultrastructural disorganization was observed in various apudocyte types.
The severity of cellular damage was dependent on the specific apudocyte type and the time elapsed since irradiation.
Degranulation emerged as the primary mechanism for hormone secretion in the delayed post-irradiation periods.

Conclusions:

Whole-body irradiation induces persistent, type-specific ultrastructural alterations in duodenal endocrine cells.
The findings highlight the long-term radiosensitivity of apudocytes and their adaptive response mechanisms, such as degranulation.