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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Overview of the Heart01:07

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The heart, a muscular organ located in the chest, functions as the body's pump, circulating blood through the vascular system. It has four chambers: two atria on top and two ventricles below. The right atrium receives deoxygenated blood from the body and passes it to the right ventricle, which pumps it to the lungs for oxygenation. The left atrium receives oxygenated blood from the lungs and transfers it to the left ventricle, which pumps it to the rest of the body.
The heart's structure...
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Related Experiment Video

Updated: Feb 20, 2026

A High-Fidelity Porcine Model of Orthotopic Heart Transplantation Following Donation after Circulatory Death
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Organ donors: heartbeating and non-heartbeating.

Gauke Kootstra1, Jur Kievit, Arjen Nederstigt

  • 1Department of Surgery, University Hospital Maastricht, PO Box 616, NL-6200 Maastricht, TheNetherlands.

World Journal of Surgery
|February 28, 2002
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Summary
This summary is machine-generated.

Organ donation faces challenges, but utilizing marginal donors and non-heart-beating (NHB) donors, particularly for kidneys with viability testing using glutathione S-transferase (GST), expands the donor pool. This approach addresses limitations in traditional heart-beating (HB) donation.

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Area of Science:

  • Transplantation Medicine
  • Nephrology
  • Organ Donation

Background:

  • Organ donation from heart-beating (HB) donors has plateaued, with initiatives like the European Donor Hospital Education Program (EDHEP) failing to significantly increase kidney and other organ availability.
  • The use of marginal donors (e.g., those with horseshoe kidneys, extremes of age, or diabetes) is proposed as a strategy to expand the donor pool.
  • Non-heart-beating (NHB) donation is explored as an additional source, particularly for kidneys.

Purpose of the Study:

  • To investigate strategies for expanding the organ donor pool beyond traditional heart-beating (HB) donors.
  • To evaluate the feasibility and utility of non-heart-beating (NHB) donors for organ transplantation, focusing on kidneys.
  • To assess the role of viability testing in selecting organs from NHB donors.

Main Methods:

  • Expanded the kidney donor pool by incorporating non-heart-beating (NHB) donors.
  • Utilized a preservation machine for NHB kidneys to enable viability testing.
  • Employed glutathione S-transferase (GST) as a biomarker to assess tubular damage and guide transplantation decisions for NHB kidneys.

Main Results:

  • The kidney donor pool was significantly enlarged through the inclusion of NHB donors.
  • Viability testing of preserved NHB kidneys, using GST levels to measure tubular damage, allows for informed decisions on transplant suitability.
  • NHB donation appears viable for kidneys and potentially livers with short warm ischemia times, but less so for other organs.

Conclusions:

  • Non-heart-beating (NHB) donors represent a crucial resource for increasing kidney transplantation rates.
  • Viability assessment using biomarkers like glutathione S-transferase (GST) is essential for optimizing the use of NHB donor kidneys.
  • Further research into NHB donation for organs other than kidneys and livers may be limited by ischemia time considerations.