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Related Experiment Videos

Intestinal and multivisceral transplantation.

Tomoaki Kato1, Phillip Ruiz, John F Thompson

  • 1Division of Transplantation, University of Miami School of Medicine, Miami, Florida 33136, USA.

World Journal of Surgery
|February 28, 2002
PubMed
Summary

Intestinal transplantation is a viable treatment for intestinal failure, with over 200 procedures performed globally. Managing rejection is crucial for improving patient and graft survival rates in these complex transplants.

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Area of Science:

  • Gastroenterology
  • Transplantation Surgery
  • Immunology

Background:

  • Intestinal failure necessitates complex management strategies.
  • Intestinal transplantation has emerged as a therapeutic option for select patients.
  • Over 200 intestinal transplant procedures have been documented worldwide.

Purpose of the Study:

  • To review the current status of intestinal transplantation.
  • To analyze outcomes, indications, and complications associated with intestinal transplantation.
  • To highlight the challenges in managing post-transplant complications, particularly rejection.

Main Methods:

  • Review of global intestinal transplant cases.
  • Analysis of patient and graft survival rates.
  • Evaluation of immunosuppression protocols and complication profiles.

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Main Results:

  • 1-year graft survival rate of 66% and patient survival rate of 54% reported.
  • Common indications include short bowel syndrome and functional abnormalities.
  • Major complications include rejection, infection, and technical issues.
  • Tacrolimus-based immunosuppression is standard and associated with improved outcomes.

Conclusions:

  • Intestinal transplantation offers a solution for intestinal failure, but with significant challenges.
  • Rejection remains the primary obstacle to improving long-term graft and patient survival.
  • Effective management of rejection is critical for advancing the field of intestinal transplantation.