Low oestriol excretion: incidence, significance and treatment in an obstetric population

In a series of 6,361 consecutive patients, low oestroil excretion late in pregnancy was detected in 871 cases (13-6%) and was associated with significantly increased incidences of still birth (P less than 0-001), neonatal death (P less than 0-001) and intrauterine growth retardation (P less than 0-001). Persistently low oestriol excretion occurred in approximately 3% of patients and two-thirds of these were suitable for conservative treatment with intravenous infusion of dextrose (25%) and fructose (20%) (2 1. of each in 48 hours). In 97 of 147 patients (65%), low oestriol excretion was favourably affected by this regimen, with significantly improved perinatal results (P less than 0-001).