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Related Experiment Videos

[Confusion and delusions occurring during interferon-alpha treatment].

N Kayser1, H Louiz, O Guillin

  • 1Service Hospitalo-Universitaire de Santé Mentale et de Thérapeutique des Professeurs H. Lôo et J.-P. Olié, CH Sainte-Anne, 7, rue Cabanis, 75014 Paris.

L'Encephale
|February 28, 2002
PubMed
Summary

Interferon alpha (IFN) therapy can cause psychiatric side effects. This case report details a patient experiencing acute confusion and delusions after IFN alpha reintroduction, resolving upon discontinuation.

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Area of Science:

  • Neuroscience
  • Oncology
  • Psychiatry

Background:

  • Interferon alpha (IFN) therapy is used for chronic myelogenous leukemia.
  • IFN therapy is associated with various psychiatric side effects, including cognitive, behavioral, and affective changes.

Observation:

  • A 52-year-old patient on long-term IFN alpha therapy for chronic myelogenous leukemia experienced an acute confusional episode with delusions.
  • This episode occurred after a 2-week suspension and subsequent reintroduction of IFN alpha.

Findings:

  • The patient's psychiatric symptoms, including confusion and delusions, resolved rapidly after discontinuing IFN alpha treatment.
  • Normal biological tests, EEG, and cerebral imaging supported a causal link between IFN alpha and the psychiatric symptoms.

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Implications:

  • This case highlights the potential for IFN alpha to induce acute psychiatric episodes, even after prolonged treatment.
  • Clinicians should monitor for psychiatric side effects during IFN alpha therapy, especially upon treatment resumption.
  • Prompt cessation of IFN alpha may lead to rapid recovery from treatment-induced psychiatric symptoms.