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Combinatorial approaches to inhibitors of VLA-4: piperazine-peptoid-bisarylureas

I Lewis1, B Rohde, M Mengus

  • 1Transplantation Research Chemistry Unit, S-507.3.03, Novartis Pharma, CH-4002 Basel, Switzerland. ian.lewis@pharma.novartis.com

Molecular Diversity
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Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...