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Combinatorial synthesis of unsymmetrical secondary amines. Application to arylethanolamines, arylpropanolamines and
S K Rastogi1, P Gupta, T Srinivasan
1Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow 226 001, India.
Molecular Diversity
|February 28, 2002
Abstract:
Combinatorial libraries of unsymmetrical secondary amines: arylethanolamine, arylpropanolamines and aryloxypropanolamines [1], in particular have been synthesized by four different routes using styrenes, aldehydes, hydroxyaromatic acids and bromoaliphatic acids. The structurally diverse libraries were generated in parallel format using solid phase methodology. The compounds corresponding to prototype I-IV were obtained in high yields and purities.