Related Experiment Videos
Analysis of genetic aberrations in uterine adenomyosis using comparative genomic hybridization
Peng-Hui Wang1, Wen-Yuann Shyong, Chi-Hung Lin
1Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, Taiwan. phwang@vghtpe.gov.tw
Objective:
To use comparative genomic hybridization (CGH) to analyzefrozen tissuesfrom adenomyosis cases to discover and map genomic regions for chromosomal gains and losses.
Study Design:
In a retrospective study, upper and lower threshold values of 1.20 and 0.80, respectively, were used to define positive findings.
Results:
No positive recurrent gene copy number alterations were detected in the 25 cases of pathologically proven adenomyosis.
Conclusion:
Although CGH is extremely useful in investigating candidate genes in the development of adenomyosis, CGH was not useful in this study. Genetic changes might be indeed extremely rare in adenomyosis, or CGH was not sensitive enough to detect candidate genes.