Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sol-gel capillary microextraction.

Shaun Bigham1, Jennifer Medlar, Abuzar Kabir

  • 1Department of Chemistry, University of South Florida, Tampa 33620-5250, USA.

Analytical Chemistry
|February 28, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nurr1 deficiency orchestrates a coupled liver-gut pathological axis revealed by multi-omics and deep-learning histopathology.

Frontiers in immunology·2026
Same author

Fenchone and cinnamyl acetate attenuate L-NAME-induced hypertension via modulation of vascular dysfunction, oxidative stress, and renal injury: An integrated network pharmacology, molecular docking, and ADMET study.

European journal of pharmacology·2026
Same author

Investigating the phytotherapeutic efficacy of <i>Acacia nilotica</i> pod ethanolic extract in modulating lipid profile, oxidative stress and inflammation in diet-induced hypercholesterolemia: <i>in vivo</i> and <i>in silico</i> insights.

Frontiers in pharmacology·2026
Same author

EACCO: Optimizing the Computation and Communication in Resource-Constrained IoT Devices for Energy-Efficient Swarm Robotics.

Sensors (Basel, Switzerland)·2026
Same author

Migraine, headache disorders, and brain health: aligning advocacy with the UN Sustainable Development Goals.

The journal of headache and pain·2026
Same author

Impact of Sodium-Glucose Cotransporter 2 Inhibitors and Mineralocorticoid Receptor Antagonists on Hypomagnesemia in Heart Failure.

Mayo Clinic proceedings·2026
Same journal

Heterojunction-Enhanced Interfacial Evanescent-Tunable Fiber Optic Probe for Amplification-free CRISPR/Cas12a-Based Rapid and Ultrasensitive Detection of MPXV.

Analytical chemistry·2026
Same journal

Tunable Charge Transfer in Europium Metal-Organic Frameworks for Ratiometric Sensing of a Sarin Simulant.

Analytical chemistry·2026
Same journal

A β-Cyclodextrin/Ag<sub>2</sub>O@MWCNT-Based Stochastic Platform for the Simultaneous Molecular Enantiorecognition and Enantioanalysis of Twelve Amino Acids in Biological Matrices.

Analytical chemistry·2026
Same journal

The ACS at 150: The History of Analytical Chemistry Publications and a Century of Progress.

Analytical chemistry·2026
Same journal

Machine Learning-Enabled Image Analysis of Complex Chemical Mixtures: Synthetic Urine Droplets as a Test System.

Analytical chemistry·2026
Same journal

H<sub>2</sub>O<sub>2</sub>/Viscosity Tandem-Locked Fluorescent Probes Based on an In Situ Fluorophore Synthesis Strategy for Colitis Imaging and Diagnosis.

Analytical chemistry·2026
See all related articles

Sol-gel capillary microextraction (sol-gel CME) offers a solventless method for preconcentrating trace analytes. This novel technique utilizes sol-gel coated capillaries for efficient extraction of diverse compounds, achieving parts per quadrillion detection limits.

Area of Science:

  • Analytical Chemistry
  • Separation Science
  • Materials Science

Background:

  • Traditional microextraction techniques often involve organic solvents, posing environmental and safety concerns.
  • Developing solventless extraction methods is crucial for sustainable analytical chemistry.
  • Capillary-based extraction offers advantages in sample volume reduction and automation.

Purpose of the Study:

  • To introduce and validate sol-gel capillary microextraction (sol-gel CME) as a novel, solventless analytical technique.
  • To evaluate the efficacy of sol-gel CME for preconcentrating a wide range of polar and nonpolar analytes.
  • To demonstrate the coupling of sol-gel CME with gas chromatography for sensitive detection.

Main Methods:

  • Utilized sol-gel poly(dimethylsiloxane) (PDMS) and sol-gel poly(ethylene glycol) (PEG) coated capillaries for analyte extraction.

Related Experiment Videos

  • Employed an in-house-assembled gravity-fed sample dispensing unit for the extraction process.
  • Analyzed extracted analytes using gas chromatography (GC) coupled with thermal desorption from the capillary.

    • Main Results:

    • Sol-gel CME successfully extracted both polar (alcohols, phenols, amines) and nonpolar (PAHs, aldehydes, ketones) analytes.
    • Achieved excellent reproducibility with run-to-run and capillary-to-capillary RSD values below 6% and 4%, respectively.
    • Demonstrated exceptional extraction sensitivity, reaching parts per quadrillion detection limits when coupled with GC-FID.

    Conclusions:

    • Sol-gel CME is a highly effective and reproducible solventless technique for trace analyte preconcentration.
    • The choice of sol-gel coating (PDMS or PEG) allows for selective extraction of different analyte polarities.
    • Further enhancements in sensitivity are anticipated with optimized capillary dimensions and sol-gel coatings.