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Related Experiment Videos

Concerted evolution between duplicated genetic elements in Helicobacter pylori.

David T Pride1, Martin J Blaser

  • 1Department of Microbiology and Immunology, Vanderbilt University, Nashville, TN, USA. prided01@med.nyu.edu

Journal of Molecular Biology
|February 28, 2002
PubMed
Summary

Geographic origin shapes Helicobacter pylori evolution. babA and babB outer membrane protein genes show evidence of recombination and concerted evolution, particularly in their 3' segments, driven by frequent gene conversions.

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Area of Science:

  • Microbiology
  • Genetics
  • Evolutionary Biology

Background:

  • Helicobacter pylori possesses outer membrane proteins (OMPs) with conserved N and C-terminal regions.
  • Understanding the evolutionary dynamics of these OMPs is crucial for comprehending H. pylori adaptation and pathogenesis.

Purpose of the Study:

  • To investigate the evolutionary relationships and mechanisms driving diversification of the babA and babB genes in H. pylori.
  • To determine the role of geographic origin and recombination in shaping the genetic landscape of these OMPs.

Main Methods:

  • Sequencing of babA and babB genes from 23 diverse H. pylori strains worldwide.
  • Phylogenetic analysis to assess inter- and intrastrain similarities.
  • Experimental validation of gene conversion frequency and mechanisms in H. pylori.

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Main Results:

  • Geographic origin is a primary determinant of phylogenetic structure, with distinct Eastern and Western divergence patterns.
  • Evidence of recombination between babA and babB, with 5' babB regions replaced by babA sequences in some strains.
  • Concerted evolution observed in the 3' segments of babA and babB, characterized by strong intrastrain similarity and reduced nucleotide substitutions, suggesting selection against diversification.
  • Experimental confirmation of frequent (10^-3), recA-dependent, and DNase-resistant gene conversions in H. pylori.

Conclusions:

  • The babA and babB genes evolve under distinct pressures, with geographic origin influencing diversification.
  • Concerted evolution in the 3' segments is driven by frequent intragenomic recombination via gene conversion.
  • These findings highlight the role of recombination and selection in shaping the OMP repertoire of H. pylori.