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Determination of arterial baroreflex-blood pressure control in conscious rats
Ding-Feng Su1, Li Chen, Xian-Bo Kong
1Department of Pharmacology, Basic Medical College, Second Military Medical University, Shanghai 200433, China. dfsu@citiz.net.
Aim:
To study the determination of arterial baroreflex-blood pressure control (ABR-BP) in conscious rats.
Methods:
Blood pressure was continuously recorded with a computerized system in conscious freely moving rats. The principle of ABR-BP measurement is to compare the pressor response to a vasoactive drug (angiotensin II) before and after the interruption of this reflex.
Results:
(1) ABR-BP values revealed by angiotensin II were closely correlated with those by phenylephrine. Doses of angiotensin II did not influence the results within certain range. (2) ABR-BP was well correlated with arterial baroreflex-heart period control (ABR-HP). (3) Anesthesia inhibited ABR-BP. There existed a circadian variation of ABR-BP in WKY rats. (4) Blood pressure variability was closely related to ABR-BP, but not to ABR-HP. (5) ABR-BP was impaired in hypertensive rats.
Conclusion:
ABR-BP is an important parameter to reflect the function of ABR. The present work makes it possible to determine ABR-BP in conscious rats. ABR-BP plays an important role in maintaining blood pressure stability and it is impaired in hypertension.