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Updated: Aug 7, 2026
The Use of Reverse Phase Protein Arrays (RPPA) to Explore Protein Expression Variation within Individual Renal Cell Cancers
Published on: January 22, 2013
[The pathology and DNA quantitative study of renal clear cell carcinoma in children]
1Department of Pathology, Shanghai Children's Hospital, Shanghai 200040, China.
Objective:
To investigate the pathological features of renal clear cell carcinoma (RCCC) in children and its relationship to the DNA content of cancer cells and DNA ploidy.
Methods:
The pathologic morphology of 4 cases of RCCC in children were observed. Using image analysis instruments the quantity of tumor cell DNA was measured.
Results:
The cytoplasm of the tumor cells were clear in all four cases. Papillary structures were present in these tumors, of which the papillary structure in two cases was over 50%, three cases had small calcified bodies with prominent bleeding and necrosis. Around tumor the glomerular and tubular of kidney always is normal the average DNA index was 1.31. They presented diploidy, high diploidy or subtetraploidy.
Conclusions:
The specific features of most RCCC in children are clear cytoplasm, most contain papillary structures, calcified bodies, often with bleeding and necrosis. Around tumor the glomerular and tubular of kidney is always normal. The DNA contents of cancer cells present diploidy, high diploidy or subtetraploidy.
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