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Gerronemins A-F, cytotoxic biscatechols from a Gerronema species
Sven Silberborth1, Anja Stumpf, Gerhard Erkel
1Lehrbereich Biotechnologie der Universität, Paul-Ehrlich-Strabetae 23, D-67663 Kaiserslautern, Germany.
Abstract:
The gerronemins A-F (1-6) were isolated as the cytotoxic components of an extract of a Gerronema species detected in a screening for new cytotoxic metabolites from basidiomycetes. Their structures were elucidated by spectroscopic techniques, and they are composed of a C12-C16 alkane or alkene substituted at both ends by 2,3-dihydroxyphenyl groups. The gerronemins blocked the inducible expression of a hCOX-2 and iNOS promoter driven reporter gene with IC50-values of 1-5 microg/ml. In addition, cytotoxic activities were observed which were due the inhibition of cellular macromolecular syntheses.