Morphologic phenotyping with MR microscopy: the visible mouse
Related Experiment Video
Updated: Oct 2, 2026
Multiple-mouse Neuroanatomical Magnetic Resonance Imaging
Published on: February 27, 2011
G Allan Johnson1, Gary P Cofer, Sally L Gewalt
1Center for In Vivo Microscopy, Duke University Medical Center, Rm 141, D Bryan Neuroscience Bldg, Research Dr, Durham, NC 27710, USA. gaj@orion.mc.duke.edu
Abstract:
A method for rapid morphologic phenotyping is demonstrated by using magnetic resonance microscopy. Whole fixed C57BL/6J mice were imaged at 110-microm isotropic resolution; limited volumes of the intact specimen, at 50-microm isotropic resolution; and isolated organs, at 25-microm isotropic resolution. The three-dimensional imaging technique was applied to uricase knockout mice to demonstrate the method for the evaluation of morphologic phenotype.
