Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hyperoxia in extreme hemodilution.

O Habler1, M Kleen, G Kemming

  • 1Department of Anaesthesiology, Ludwig Maximilians University Munich, Germany. oliver.habler@helios.med.uni.muenchen.de

European Surgical Research. Europaische Chirurgische Forschung. Recherches Chirurgicales Europeennes
|February 28, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

German guidelines for airway management 2023.

Die Anaesthesiologie·2024
Same author

[Structured patient handover in high-risk areas : Evidence and recommendations for the practical implementation].

Die Anaesthesiologie·2023
Same author

[Advance Care Planning-further development of the patient advance directive : What the specialist in internal medicine must know].

Der Internist·2022
Same author

[Short version of the 2nd edition of the German-Austrian S3 guidelines "Cardiogenic shock complicating myocardial infarction-Diagnosis, monitoring and treatment"].

Der Anaesthesist·2020
Same author

Higher procoagulatory potential but lower DIC score in COVID-19 ARDS patients compared to non-COVID-19 ARDS patients.

Thrombosis research·2020
Same author

[Publish via open access thanks to the DEAL agreement : Give your scientific articles the widest possible distribution].

Der Anaesthesist·2020

Intraoperative normovolemic hemodilution combined with hyperoxic ventilation can reduce the need for red blood cell transfusions during major surgery. This strategy enhances oxygen delivery and tissue oxygenation, proving safe and effective.

Area of Science:

  • Anesthesiology
  • Surgical Hemodynamics
  • Transfusion Medicine

Background:

  • Intraoperative blood loss is initially managed with cell-free solutions, leading to dilutional anemia.
  • Normovolemia is maintained by increased cardiac output and oxygen extraction.
  • Extreme hemodilution may necessitate red blood cell transfusion, risking loss of transfused cells if bleeding isn't controlled.

Purpose of the Study:

  • To evaluate the efficacy of combining intraoperative hemodilution with hyperoxic ventilation.
  • To determine if this combined approach can reduce allogeneic red blood cell transfusion needs.
  • To assess the safety and effectiveness in preserving tissue oxygenation during major blood loss.

Main Methods:

  • Intraoperative normovolemic hemodilution was employed.

Related Experiment Videos

  • Patients received 100% oxygen ventilation (hyperoxic ventilation).
  • Hemodynamic compensation and tissue oxygenation were monitored in hemodiluted subjects.

    • Main Results:

    • Hyperoxic ventilation effectively increased arterial oxygen content via dissolved oxygen.
    • No hyperoxia-associated microcirculatory dysregulation or impaired tissue oxygenation was observed in hemodiluted subjects.
    • The combination strategy enlarged the safety margin for hemodynamic compensation and tissue oxygenation.

    Conclusions:

    • Hyperoxic hemodilution is a safe, cost-effective, and efficient method to reduce allogeneic transfusions in high-blood-loss surgeries.
    • This approach enhances oxygen transport and tissue oxygenation in hemodiluted patients.
    • The findings support hyperoxic hemodilution as a valuable adjunct to transfusion management.