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CT findings of leukemic pulmonary infiltration with pathologic correlation
Nobuyuki Tanaka1, Tsuneo Matsumoto, Gouji Miura
1Department of Radiology, Yamaguchi University School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan. ntanaka@po.cc.yamaguchi-u.ac.jp
European Radiology
|February 28, 2002
Summary
Characteristic CT scan findings can help identify pulmonary infiltration in leukemia patients. Key indicators include thickened blood vessels and airways, and specific patterns of lung opacity, correlating with pathological evidence of leukemic spread.
Area of Science:
- Radiology
- Oncology
- Pulmonology
Background:
- Pulmonary infiltration is a significant complication in leukemia patients.
- Accurate diagnosis of leukemic pulmonary infiltration is crucial for patient management.
Purpose of the Study:
- To correlate computed tomography (CT) findings with pathological results in leukemic pulmonary infiltration.
- To identify characteristic CT features suggestive of leukemic infiltration in the lungs.
Main Methods:
- Retrospective analysis of CT scans from 11 leukemia patients with pulmonary infiltration.
- Comparison with CT scans from 22 leukemia patients without pulmonary infiltration (control group).
- Evaluation of CT-pathologic correlations in 7 patients.
Main Results:
- Thickening of bronchovascular bundles (81.8%) and prominence of peripheral pulmonary arteries (81.8%) were frequent findings.
- Non-lobular, non-segmental ground-glass opacities (90.9%) were also common.
- These findings, particularly thickened bronchovascular bundles and prominent arteries, were significantly more frequent in the leukemic infiltration group and correlated with peribronchovascular leukemic cell infiltration.
Conclusions:
- Thickening of bronchovascular bundles and prominence of peripheral pulmonary arteries on CT are suggestive findings for leukemic pulmonary infiltration.
- CT imaging can effectively visualize leukemic cell infiltration patterns within the pulmonary parenchyma, aiding diagnosis.