Preventing fungal infections in immunocompromised patients

E Johnson1, M Gilmore, J Newman

  • 1Public Health Laboratory Service, Mycology Reference Laboratory, Bristol.

British Journal of Nursing (Mark Allen Publishing)
|March 1, 2002
PubMed

Insights

Nurses play a vital role in managing systemic fungal infections in immunocompromised patients. Early recognition of risk factors and proper patient education are crucial for preventing these infections.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Hematology

Background:

  • Systemic fungal infections are rising in immunosuppressed individuals, especially bone marrow transplant recipients and those with prolonged neutropenia.
  • Environmental factors can exacerbate the risk of fungal exposure and subsequent infection.
  • Existing preventive strategies include environmental controls and chemoprophylaxis.

Purpose of the Study:

  • To discuss the critical role of nurses in managing patients at risk of systemic fungal infections.
  • To identify key areas for nursing intervention in preventing and managing these infections.
  • To address challenges associated with antifungal therapy in at-risk patient populations.

Main Methods:

  • A meeting convened by the European Group for Blood and Marrow Transplantation (UK) Nurses and Allied Professionals Group.
  • Discussion focused on nursing responsibilities and challenges in managing at-risk patients.
  • Review of current preventive measures and antifungal treatment issues.

Main Results:

  • Nurses must be adept at recognizing risk factors for systemic fungal infections.
  • Effective patient education and feedback are essential nursing functions.
  • Challenges in antifungal therapy, including non-compliance and side effects, require nursing attention.

Conclusions:

  • Nurses are central to the multidisciplinary approach to preventing and managing systemic fungal infections.
  • Enhanced nursing education and protocols can improve patient outcomes.
  • Addressing practical challenges of antifungal treatment is key to successful management.

Related Concept Videos

Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Transmission-based Precautions II: Airborne and Protective Environment01:25

Transmission-based Precautions II: Airborne and Protective Environment

Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
Standard Precaution01:26

Standard Precaution

Standard precautions are the minimum infection control safeguards used while caring for all patients, irrespective of their disease condition. They help prevent the spread of common infectious microorganisms to healthcare workers, patients, and visitors in all healthcare settings.
Hand hygiene is the most crucial means to prevent the transmission of disease. Employers are legally required to provide their workers with personal protective equipment (PPE) to minimize exposure or contact with...
Transmission-based Precautions I: Contact, Enteric, and Droplets01:17

Transmission-based Precautions I: Contact, Enteric, and Droplets

Transmission-based precautions are for patients known to be infected or suspected to be infected or colonized with organisms that pose a significant risk to others. Some transmission-based precautions include contact, enteric, and droplet.
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...