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Failure of oral antimicrobial agents in eradicating gastrointestinal colonization with vancomycin-resistant
1Department of Internal Medicine Specialties, The University of Texas M. D. Anderson Cancer Center, Houston 77030, USA.
Infection Control and Hospital Epidemiology
|March 1, 2002
Abstract:
Eradication of gastrointestinal colonization with vancomycin-resistant enterococci (VRE) using a combination of oral bacitracin and gentamicin was evaluated. Twenty-eight evaluable treated patients were matched with 28 control patients. After 3 months of follow-up, 5 patients (18%) in the treatment group versus 1 patient (4%) in the control group (P = .2) had negative results on stool cultures, with a similar frequency of VRE bacteremia (P = .8). The use of oral bacitracin plus gentamicin did not reduce VRE colonization or bacteremia.