Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chemoembolization for primary liver cancer.

T Achenbach1, J K Seifert, M B Pitton

  • 1Klinik für Radiologie, Johannes Gutenberg-Universität, Mainz, Germany.

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
|March 1, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparison of resection and transarterial chemoembolisation in the treatment of advanced intrahepatic cholangiocarcinoma--a single-center experience.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2013
Same author

The durability of the intrascaphoid compression of headless compression screws: in vitro study.

The Journal of hand surgery·2012
Same author

Comparison of fluoroscopy-guided Pull-type percutaneous radiological gastrostomy (Pull-type-PRG) with conventional percutaneous radiological gastrostomy (Push-type-PRG): clinical results in 253 patients.

European radiology·2011
Same author

Bone mineral density and vitamin D status in female and male patients with osteoarthritis of the knee or hip.

European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes·2008
Same author

Quality of care of VLBW neonates: relationship between unit volume and outcome is different between metropolitan and rural regions.

Acta paediatrica (Oslo, Norway : 1992)·2008
Same author

About objective 3-d analysis of airway geometry in computerized tomography.

IEEE transactions on medical imaging·2008

Transarterial chemoembolization (TACE) with lipiodol and mitomycin C shows antitumoural efficacy for primary liver cancer. However, this treatment did not significantly improve patient survival, indicating a need for new therapeutic options.

Area of Science:

  • Hepatology
  • Oncology
  • Interventional Radiology

Background:

  • Primary liver cancer, particularly hepatocellular carcinoma, often presents in patients unsuitable for surgery.
  • Prognosis for untreated primary liver cancer is generally poor.
  • Transarterial chemoembolization (TACE) is a potential treatment modality for unresectable liver cancer.

Purpose of the Study:

  • To evaluate the morbidity and efficacy of transarterial chemoembolization (TACE) using lipiodol and mitomycin C for patients with primary liver cancer.
  • To assess treatment response in terms of tumor size and alpha-fetoprotein (AFP) levels.
  • To determine the impact of TACE on patient survival.

Main Methods:

  • A prospective case-control study involving 22 patients with non-resectable hepatocellular carcinoma.

Related Experiment Videos

  • Treatment consisted of TACE with lipiodol and mitomycin C.
  • Repeat treatments were administered every 4-6 weeks up to seven times based on response.

    • Main Results:

    • Morbidity associated with TACE was 23% and generally minor, with no 30-day mortality.
    • Radiological response (tumor shrinkage or stable size) was observed in 70% of patients.
    • AFP reduction occurred in 63% of patients with elevated levels.
    • Median survival was 14 months, with 1-year and 2-year survival rates of 69% and 29%, respectively.
    • No significant difference in survival was noted between radiological or AFP responders and non-responders.

    Conclusions:

    • TACE with lipiodol and mitomycin C demonstrates significant antitumoural effects in primary liver cancer, evidenced by radiological and tumor marker responses.
    • Despite these effects, TACE did not show a clear impact on patient survival.
    • There is a critical need for novel treatment strategies that can improve survival outcomes for patients with primary liver cancer.