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Related Experiment Videos

Region-specific gastrointestinal Hox code during murine embryonal gut development.

Yasuhiro Kawazoe1, Tomohisa Sekimoto, Masatake Araki

  • 1Department of Developmental Genetics, Institute of Molecular Embryology and Genetics, Kumamoto University, 4-24-1 Kuhonji, Kumamoto 862-0976, Japan.

Development, Growth & Differentiation
|March 1, 2002
PubMed
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Hox genes establish the digestive tract's anterior-posterior pattern. Their specific expression patterns, or "Hox code," differ across the foregut, midgut, and hindgut, guiding regional development.

Area of Science:

  • Developmental Biology
  • Genetics

Background:

  • Hox genes are crucial transcription factors specifying body parts along the anteroposterior axis during embryogenesis.
  • Understanding Hox gene function in digestive tract development is key to deciphering anteroposterior patterning.

Purpose of the Study:

  • To systematically examine Hox gene expression patterns in the developing digestive tract.
  • To clarify the role of Hox genes in anteroposterior pattern formation of the gut.

Main Methods:

  • Whole-mount and section in situ hybridization were used to analyze Hox gene expression.
  • Expression patterns of Hox genes from paralogous groups 4-9 were examined in developing mouse gut at 12.5 days post-coitum.

Main Results:

  • HoxA and HoxB genes (groups 4-8) were expressed in the stomach, unlike HoxC and HoxD genes.

Related Experiment Videos

  • Colinear expression of Hox genes, forming a
  • Hox code,
  • was observed in the midgut, with 3' genes expressed rostrally and 5' genes caudally.
  • Distinct Hox codes were identified for the foregut, midgut, and hindgut subdomains.

    • Conclusions:

    • A specific Hox code exists for each digestive tract subdomain (foregut, midgut, hindgut).
    • Hox gene expression, primarily in the visceral mesoderm, suggests a role in mesenchymal specification.
    • Epithelial-mesenchymal interactions mediate regional differentiation of gut subdomains through the Hox code.