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Nutritional supplementation for stable chronic obstructive pulmonary disease.

I M Ferreira1, D Brooks, Y Lacasse

  • 1Respiratory Division, University of Toronto, 82 Buttonwood, Toronto, Ontario, Canada, M6M 2J5. ivoneferreira@hotmail.com

The Cochrane Database of Systematic Reviews
|March 1, 2002
PubMed
Summary

Nutritional supplementation did not significantly improve outcomes for patients with stable chronic obstructive pulmonary disease (COPD). This review found no significant effect on body weight, lung function, or exercise capacity in COPD patients receiving caloric support.

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Area of Science:

  • Pulmonary Medicine
  • Nutritional Science
  • Clinical Trials

Background:

  • Low body weight in COPD patients correlates with worse pulmonary status, reduced exercise capacity, and increased mortality.
  • Nutritional support is considered a potential intervention for improving outcomes in COPD management.

Purpose of the Study:

  • To systematically review randomized controlled trials (RCTs) assessing the impact of nutritional supplementation on stable COPD patients.
  • To evaluate effects on anthropometric measures, pulmonary function, respiratory muscle strength, and exercise capacity.

Main Methods:

  • Systematic review of RCTs sourced from the Cochrane Airways Group register, meeting abstracts, and expert consultations.
  • Data extraction and quality assessment by two independent reviewers, with effect sizes pooled using a random-effects model.

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Main Results:

  • Nine RCTs were included; six were high quality, and two were double-blinded.
  • Nutritional support demonstrated small effects across all outcomes, with confidence intervals including zero.
  • No significant improvements were observed in anthropometric measures, lung function, or exercise capacity.

Conclusions:

  • Nutritional support does not appear to significantly benefit patients with stable COPD regarding key health indicators.
  • Further research may be needed to explore specific nutritional interventions or patient subgroups.