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Related Experiment Videos

Pygeum africanum for benign prostatic hyperplasia.

T Wilt1, A Ishani, R Mac Donald

  • 1General Internal Medicine (111-0), Minneapolis VA/VISN 13 Center for Chronic Disease Outcomes Research, One Veterans Drive, Minneapolis, Minnesota 55417, USA. Tim.Wilt@med.va.gov

The Cochrane Database of Systematic Reviews
|March 1, 2002
PubMed
Summary

Pygeum africanum extract moderately improves urinary symptoms and flow in men with benign prostatic hyperplasia (BPH). Adverse effects were mild and comparable to placebo, but more research is needed.

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Area of Science:

  • Urology
  • Pharmacognosy
  • Evidence-based Medicine

Background:

  • Benign prostatic hyperplasia (BPH) causes lower urinary tract symptoms (LUTS).
  • Phytotherapy, using plant extracts like Pygeum africanum, is increasingly used for BPH symptoms.
  • Pygeum africanum is a common herbal treatment for BPH.

Purpose of the Study:

  • To evaluate the efficacy of Pygeum africanum extracts compared to placebo for BPH.
  • To assess if Pygeum africanum is as effective as standard BPH pharmacotherapies.
  • To determine the side effect profile of Pygeum africanum versus conventional BPH drugs.

Main Methods:

  • Systematic review of 18 randomized controlled trials (RCTs) involving 1562 men with BPH.
  • Searched major databases (MEDLINE, EMBASE, Cochrane) and contacted manufacturers.

Related Experiment Videos

  • Included RCTs comparing Pygeum africanum to placebo or other BPH medications, assessing urologic symptoms and urodynamic measures.

    • Main Results:

    • Pygeum africanum showed a moderate improvement in urologic symptoms and flow measures compared to placebo (effect size -0.8 SD).
    • Men using Pygeum africanum were over twice as likely to report symptom improvement (RR=2.1).
    • Significant improvements observed in nocturia (-19%), residual urine volume (-24%), and peak urine flow (+23%); mild side effects.

    Conclusions:

    • Standardized Pygeum africanum extract may benefit men with LUTS due to BPH.
    • Current evidence is limited by small study sizes, short durations, varied doses, and inconsistent outcome reporting.
    • Further large-scale, long-duration RCTs are needed, comparing Pygeum africanum to placebo and active treatments using standardized measures.